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April 2003Print this Page

MIZZOU NEWS FEATURE STORY

Rebecca Johnson and Richard Meadows with Lady Jane
Rebecca Johnson and Richard Meadows pose with Lady Jane. They are conducting comparative studies to see if the beneficial human chemical changes that occur with dogs still happen if the animal is made out of metal and electronics. The results could suggest new ways to treat a variety of human ailments such as cancer and depression. Photos courtesy of the MU College of Veterinary Medicine

Lady Jane, the Robot Dog

She's just like any dog, except for the wires and computer chips

By Randy Mertens

It's no secret that pets make people feel good. Today, scientific research has measured human chemical responses that indicate petting a dog can lower a person's blood pressure, owning a cat can positively change body chemistry, and caring for an animal will enhance the human body's immune system.

Those results pose an interesting question: Are these chemical changes the result of happy interaction or is there something within the living animal itself that triggers the response?

To find out, two scientists are asking a robot dog for help.

Richard Meadows, director of the University of Missouri’s College of Veterinary Medicine's community practice section, and Rebecca Johnson, the Millsap Professor of Gerontological Nursing and Public Policy at MU's Sinclair School of Nursing, are the two scientists involved. They are conducting comparative studies to see if the beneficial human chemical changes that are known to occur with dogs still happen if the animal is made out of metal and electronics.

The results could suggest new ways to treat a variety of human ailments like cancer and depression. Combined with other scientific studies, the results may also give new insight into ways to enhance other known byproducts of pleasurable human-animal relationships such as delaying the aging process, promoting better mental health, and even preventing medical problems.

The study began in September. Fifty pet owners and 50 non-pet owners had their blood chemistry measured to establish a baseline measurement. They will then be connected to a continuous blood pressure sensing device. They then interact with a real dog. When the blood pressure drops by five percent, indicating a change in body chemistry, blood will be drawn and measured for chemical indicators known to be associated with health and feelings of well being. The study will then be repeated with the robot dog and a control group.

The research team is also looking for any chemical changes that occur between animal owners and their dogs, and non-animal owners to friendly but unfamiliar dogs. The team also wants to see if beneficial human chemical effects are sustained with the robot dog as they are known to be with a real animal.

The findings will then be compared, revealing something about, perhaps, part of the age-old mysteries of human-animal partnership.


Expanding on earlier discoveries

The MU work is an extension on the scientific findings of Dr. Johannes Stefanus Joubert Odendaal of South Africa. His contribution to science is not merely noting that people feel better after interacting with an animal, but measuring the effect on human body functions. His scientific studies show that the comfortable feeling you get by interacting with a companion animal is no accident—it's chemistry. And, his studies indicate that its effects go way beyond the warm and fuzzy.

Lady Jane with pink ball

Dr. Odendaal is as a professor and research development director of the Life Sciences Institute, Technikon Pretoria, South Africa. Dr. Odendaal is uniquely qualified to pursue this research. His academic achievements have few rivals in the world. In addition to his veterinary medical degree, he holds no fewer than three doctoral degrees: a DVSc (the equivalent to a PhD) in Veterinary Science, a DPhil in Psychology, and a PhD in Physiology. In 1993, he earned membership in the Royal College of Veterinary Surgeons, London.

Dr. Odendaal's latest scientific study involved six clinically depressed people who were each given a dog to visit with for 30 minutes a day. The group's blood makeup was measured before introduction of the animal and found, not unexpectedly, to be low in the amino acid precursors of chemicals that create pleasure and joy, serotonin, phenyletylamine, and dopamine. After the dogs were introduced, the amino acid precursors of these chemicals increased in their blood serum. The people also reported that they feel less depressed. This was the first time such a therapeutic relationship between animals and humans was scientifically measured. This pilot study could provide a safe, natural, and effective alternative to treating the clinically depressed with pharmaceuticals — with the attendant costs and side effects.

Earlier, groundbreaking studies have shown that among both humans and dogs, beneficial changes occur in several key hormone levels including beta endorphin, beta phenylethylamine, prolactin, dopamine, and oxytocin within about 15 minutes of a positive interaction between animal and human. The release of these chemicals not only makes people happy, but also strengthens the immune system, and, according to Dr. Odendaal’s findings, counteracts the production of bad chemicals that can lead to cancer or other diseases. The stress hormone cortisol, decreased during this study.

To many researchers, the most exciting facet is evidence from a Dr. Odendaal study that positive human-animal interaction may delay production of bad body chemicals associated with diseases such as cancer. It's a double-whammy, too, as the study indicates an improvement in body chemicals associated with a healthy immune system. We may soon see a time when people at risk for certain cancers may be prescribed a pet to help delay onset of the disease, Dr. Odendaal said.

But, is it the living dog or the pleasant interaction that triggers the changes?

It is no accident that MU has connected with Dr. Odendaal. The MU College of Veterinary Medicine recently launched the Center for the Study of Animal Wellness (CSAW), a virtual center aimed at fostering research to demonstrate the beneficial effects of human-animal interaction. In association with the MU Sinclair School of Nursing, a major goal of CSAW is developing research models that reach across species and disciplines. For example, CSAW is looking into how interacting with a dog can affect anxiety, depression, fatigue, and sense of coherence among cancer patients.


Funded by someone who knows the significance

The study is being funded through the non-profit Veterinary Pet Insurance Skeeter Foundation. The foundation is designed to help validate and promote the human-animal bond, perpetuate the positive effects that pets have on human health, and to educate people about the immense value pets can provide to society. It was founded in 1980 by Dr. Jack Stephens, a tough Oklahoma cowboy who went on to earn his DVM from the MU College of Veterinary Medicine and who later started Veterinary Pet Insurance.

Lady Jane with green light

Dr. Stephens is more than an interested sponsor. He’ll tell you it was his connection to a little dog named Spanky that helped him survive his cancer.

Diagnosed with stage four throat cancer, Dr. Stephens was given only six months to live in 1989. Initially, his little dog Spanky annoyed Dr. Stephens by demanding so much attention. He followed Dr. Stephens everywhere, including his radiation treatments. In Dr. Stephens’ long sleepless nights that followed, Spanky seemed to know how to help. “Sometimes I’d be real sick afterward and he knew when, where, and how to approach,” Dr. Stephens said.

Spanky also made him exercise. “If he hadn’t done that, I would have just sat around feeling sorry for myself,” Dr. Stephens said. “That is the downward spiral of cancer that I think that pets definitely help you overcome.”

Spanky’s insistence of interacting with Dr. Stephens over a long period of time may ask an intriguing question — what if Dr. Stephens could have turned off Spanky as one might a robot dog?

Dr. Stephens’ cancer is now in remission. He is so convinced of the medical benefits of animals that he has created a foundation to grant money to researchers investigating the healing power of pets — including the Center for the Study of Animal Wellness at the MU College of Veterinary Medicine.

Preliminary results of the study will be available within a year.

Raising Lady Jane

The $1,500 commercially-available robotic dog found its way to the MU College of Veterinary Medicine through some old friends, benefactors Ken and Barbara Levy of St. Louis. The robot was named Lady Jane in honor of the Levy’s Cavalier King Charles Spaniel dog who had recently died.

The animated robot represents the latest in artificial intelligence — a computer’s ability to sense its surroundings and learn from them. The computer’s mission, aided by sonar and voice recognition software, is to sense the presence of people and interact with them in many of the same ways that a real dog might. The robot also howls, cries, sneezes, shakes its body, and blinks its angry red and happy green eyes. A blue light near its tail indicates contentment.

Lady Jane resting

Getting to the point where the mechanical dog could be used in the research study was a project in itself. The robot is programmed to come out of the box as an infant. As it learns, as a real dog would it goes through different stages: toddler, childhood, adolescence, teenager, and adult.

“When the mechanical Lady Jane came out of the box she did nothing but lay there and cry,” said Dr. Rebecca Johnson.

Students assisted with the socialization of the robot, a process that took several months. The students stroked the sensors on the robot’s back, chin, and feet. Occasionally, Lady Jane would react with flashing eyes and an electronic beep. Left alone, she would cry and squirm.

Lady Jane’s programming finally decided to leave infancy and to stand up. “There were about seven or eight of us watching,” Dr. Johnson said. “Suddenly, she stood up and took a step or two. Everyone applauded.”

Adolescence was a terrible time for Lady Jane,” Dr. Johnson recalled. “She was totally non-compliant. She wouldn’t answer with her usual tones.”

Lady Jane stayed so long in adolescence that the researchers thought there was a mechanical fault. The turning point came during a social gathering where Lady Jane apparently got over-stimulated and went under the sofa with her angry red lights flashing.

“She sort of went ballistic that night, so I put her on the charger,” Dr. Johnson said. “The next day she raised her paw to signal she was going to be an adult.”


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